P63 and p73 transcriptionally regulate genes involved in DNA repair.
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ABSTRACT:
SUBMITTER: Lin YL
PROVIDER: S-EPMC2752189 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
p63 and p73 transcriptionally regulate genes involved in DNA repair.
Lin Yu-Li YL Sengupta Shomit S Gurdziel Katherine K Bell George W GW Jacks Tyler T Flores Elsa R ER
PLoS genetics 20091009 10
The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that they activate a unique transcriptional network. Therefore, we performed a genome-wide analysis using cells lacking the p53 family members after treatment with DNA damage. We identified over 100 genes involved in multiple pathways that were uniquely regulated by p63 or p73, and no ...[more]
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