Systems genetics of complex traits in Drosophila melanogaster.
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ABSTRACT:
SUBMITTER: Ayroles JF
PROVIDER: S-EPMC2752214 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Systems genetics of complex traits in Drosophila melanogaster.
Ayroles Julien F JF Carbone Mary Anna MA Stone Eric A EA Jordan Katherine W KW Lyman Richard F RF Magwire Michael M MM Rollmann Stephanie M SM Duncan Laura H LH Lawrence Faye F Anholt Robert R H RR Mackay Trudy F C TF
Nature genetics 20090222 3
Determining the genetic architecture of complex traits is challenging because phenotypic variation arises from interactions between multiple, environmentally sensitive alleles. We quantified genome-wide transcript abundance and phenotypes for six ecologically relevant traits in D. melanogaster wild-derived inbred lines. We observed 10,096 genetically variable transcripts and high heritabilities for all organismal phenotypes. The transcriptome is highly genetically intercorrelated, forming 241 tr ...[more]
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