Over-expression and localization of a host protein on the membrane of Cryptosporidium parvum infected epithelial cells.
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ABSTRACT:
SUBMITTER: Yang YL
PROVIDER: S-EPMC2752322 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
Over-expression and localization of a host protein on the membrane of Cryptosporidium parvum infected epithelial cells.
Yang Yi-Lin YL Serrano Myrna G MG Sheoran Abhineet S AS Manque Patricio A PA Buck Gregory A GA Widmer Giovanni G
Molecular and biochemical parasitology 20090722 1
The genus Cryptosporidium includes several species of intestinal protozoan parasites which multiply in intestinal epithelial cells. The impact of this infection on the transcriptome of cultured host cells was investigated using DNA microarray hybridizations. The expression of 14 genes found to be consistently up- or down-regulated in infected cell monolayers was validated with RT PCR. Using immunofluorescence we examined the expression of Protease Activated Receptor-2, which is encoded by one of ...[more]
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