Unknown

Dataset Information

0

Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach.


ABSTRACT: BACKGROUND:Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce. METHODS:Using leukocyte DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the relationship of mean telomere repeat copy number to single gene copy number (T/S ratio), using a re-modified quantitative polymerase chain reaction protocol, among 337 white males who subsequently developed an incident myocardial infarction (MI), and among an equal number of age- and smoking-matched white males who remained free of reported vascular disease during follow-up (controls). RESULTS:The mean follow-up time since randomization was 3.85 y. The T/S ratio was inversely correlated with age in the controls (R=-0.114; p=0.036). The log(e)-transformed T/S ratios were significantly smaller in the MI cases (3.41+/-0.63) than the MI controls (3.52+/-0.78) (p=0.01). In a multi-variable adjusted analysis, decreased T/S ratio was significantly associated with risk of MI (odds ratio=1.621; 95%CI=1.140-2.304; p=0.007). CONCLUSIONS:The present investigation has shown an association of telomere length shortening with increased risk of incident myocardial infarction, further suggesting the importance of telomere biology in atherogenesis.

SUBMITTER: Zee RY 

PROVIDER: S-EPMC2752372 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach.

Zee Robert Y L RY   Michaud Sherri E SE   Germer Soren S   Ridker Paul M PM  

Clinica chimica acta; international journal of clinical chemistry 20090213 1-2


<h4>Background</h4>Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce.<h4>Methods</h4>Using leukocyte DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the relationship of mean telomere repeat copy number to single gene copy number (T/S ratio), using a re-modified quantitative polymerase chain reaction protocol,  ...[more]

Similar Datasets

| S-EPMC3817489 | biostudies-literature
| S-EPMC4680942 | biostudies-other
| S-EPMC3622729 | biostudies-literature
| S-EPMC3773906 | biostudies-literature
| S-EPMC4751225 | biostudies-literature
| S-EPMC5081046 | biostudies-literature
| S-EPMC5398935 | biostudies-literature
| S-EPMC4233346 | biostudies-other
| S-EPMC7766074 | biostudies-literature
| S-EPMC5051547 | biostudies-literature