Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC2752387 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Kumar Satish S Hernandez David D Hoa Brenda B Lee Yuna Y Yang Julie S JS McCurdy Alison A
Organic letters 20080723 17
A light-controlled reversible binding switch based on photochromic 3H-naphtho[2,1-b]pyran is under development for studying cellular oscillatory calcium signals. The binding affinities of the closed and open forms of substituted naphthopyran 1 for Ca(2+), Mg(2+), and Sr(2+) in buffer were determined. The photochemically ring-opened form of the receptor exhibited increased affinity compared to the thermally stable closed form of the receptor. The binding affinity difference for Ca(2+) was approxi ...[more]