Calorie restriction alters mitochondrial protein acetylation.
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ABSTRACT:
SUBMITTER: Schwer B
PROVIDER: S-EPMC2752488 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Calorie restriction alters mitochondrial protein acetylation.
Schwer Bjoern B Eckersdorff Mark M Li Yu Y Silva Jeffrey C JC Fermin Damian D Kurtev Martin V MV Giallourakis Cosmas C Comb Michael J MJ Alt Frederick W FW Lombard David B DB
Aging cell 20090709 5
Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry screening, we identify 72 candidate proteins involved in a variety of metabolic pathways with altered acety ...[more]
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