Ontology highlight
ABSTRACT:
SUBMITTER: Meechan DW
PROVIDER: S-EPMC2752572 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Meechan Daniel W DW Tucker Eric S ES Maynard Thomas M TM LaMantia Anthony-Samuel AS
Proceedings of the National Academy of Sciences of the United States of America 20090910 38
The 22q11 deletion (or DiGeorge) syndrome (22q11DS), the result of a 1.5- to 3-megabase hemizygous deletion on human chromosome 22, results in dramatically increased susceptibility for "diseases of cortical connectivity" thought to arise during development, including schizophrenia and autism. We show that diminished dosage of the genes deleted in the 1.5-megabase 22q11 minimal critical deleted region in a mouse model of 22q11DS specifically compromises neurogenesis and subsequent differentiation ...[more]