Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC2752669 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Li Mei M Duc Anne-Cécile E AC Klosi Edvin E Pattabiraman Srividya S Spaller Mark R MR Chow Christine S CS
Biochemistry 20090901 35
For almost five decades, antibiotics have been used successfully to control infectious diseases caused by bacterial pathogens. More recently, however, two-thirds of bacterial pathogens exhibit resistance and are continually evolving new resistance mechanisms against almost every clinically used antibiotic. Novel efforts are required for the development of new drugs or drug leads to combat these infectious diseases. A number of antibiotics target the bacterial aminoacyl-tRNA site (A site) of 16S ...[more]