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Predictive genomics of cardioembolic stroke.


ABSTRACT: Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver operating characteristic curve relative to that of the individual single nucleotide polymorphism with the highest prognostic performance (area under the receiver operating characteristic curve=60%).

SUBMITTER: Ramoni RB 

PROVIDER: S-EPMC2752697 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Predictive genomics of cardioembolic stroke.

Ramoni Rachel Badovinac RB   Himes Blanca E BE   Sale Michele M MM   Furie Karen L KL   Ramoni Marco F MF  

Stroke 20081208 3 Suppl


Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver operating characteristic curve relative to that of the individual single nucleotide polymorphism with the highest prognostic performance (area unde  ...[more]

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