Ontology highlight
ABSTRACT:
SUBMITTER: Keene KL
PROVIDER: S-EPMC2752813 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Keene Keith L KL Mychaleckyj Josyf C JC Smith Shelly G SG Leak Tennille S TS Perlegas Peter S PS Langefeld Carl D CD Herrington David M DM Freedman Barry I BI Rich Stephen S SS Bowden Donald W DW Sale Michèle M MM
Human genetics 20080228 4
We previously investigated the estrogen receptor alpha gene (ESR1) as a positional candidate for type 2 diabetes (T2DM), and found evidence for association between the intron 1-intron 2 region of this gene and T2DM and/or nephropathy in an African American (AA) population. Our objective was to comprehensively evaluate variants across the entire ESR1 gene for association in AA with T2DM and end stage renal disease (T2DM-ESRD). One hundred fifty SNPs in ESR1, spanning 476 kb, were genotyped in 577 ...[more]