Ontology highlight
ABSTRACT:
SUBMITTER: Choi EY
PROVIDER: S-EPMC2753175 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20081101 5904
Leukocyte recruitment to sites of infection or inflammation requires multiple adhesive events. Although numerous players promoting leukocyte-endothelial interactions have been characterized, functionally important endogenous inhibitors of leukocyte adhesion have not been identified. Here we describe the endothelially derived secreted molecule Del-1 (developmental endothelial locus-1) as an anti-adhesive factor that interferes with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Endo ...[more]