Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC2753268 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Wu Yinghao Y Dousis Athanasios D AD Chen Mingzhi M Li Jialin J Ma Jianpeng J
Journal of molecular biology 20081110 4
In this article, we present a de novo method for predicting protein domain boundaries, called OPUS-Dom. The core of the method is a novel coarse-grained folding method, VECFOLD, which constructs low-resolution structural models from a target sequence by folding a chain of vectors representing the predicted secondary-structure elements. OPUS-Dom generates a large ensemble of folded structure decoys by VECFOLD and labels the domain boundaries of each decoy by a domain parsing algorithm. Consensus ...[more]