Ontology highlight
ABSTRACT:
SUBMITTER: Pearson MS
PROVIDER: S-EPMC2753299 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Pearson M S MS McManus D P DP Smyth D J DJ Jones M K MK Sykes A M AM Loukas A A
Parasitology 20070823 Pt.14
A partial cDNA sequence was obtained from the human blood fluke, Schistosoma mansoni using a signal sequence trap approach. The full-length cDNA was cloned and termed Sm-7TM. The corresponding open reading frame had 7 membrane spanning domains and shared identity with a small, novel group of seven transmembrane (7TM) receptors from vertebrates and invertebrates, including the human ee3 receptor - a heptahelical protein implicated in neuronal signalling. Phylogenetic analysis of this novel family ...[more]