Ontology highlight
ABSTRACT:
SUBMITTER: Chavez D
PROVIDER: S-EPMC2753388 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Chavez Deborah D Guerra Bernadette B Lanford Robert E RE
Virology 20090607 2
GBV-B induces hepatitis in tamarins and marmosets and is a surrogate model for HCV infections. Here, we cloned and characterized the antiviral activity of tamarin and marmoset interferon (IFN)alpha and IFN gamma. Potent antiviral activity was observed for tamarin and marmoset IFN alpha in primary hepatocyte cultures infected with GBV-B. The antiviral activity was greater in cultures exposed to IFN alpha prior to GBV-B infection, suggesting that either GBV-B was capable of inhibition of the antiv ...[more]