V3 spinal neurons establish a robust and balanced locomotor rhythm during walking.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC2753604 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
V3 spinal neurons establish a robust and balanced locomotor rhythm during walking.
Zhang Ying Y Narayan Sujatha S Geiman Eric E Lanuza Guillermo M GM Velasquez Tomoko T Shanks Bayle B Akay Turgay T Dyck Jason J Pearson Keir K Gosgnach Simon S Fan Chen-Ming CM Goulding Martyn M
Neuron 20081001 1
A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severe ...[more]
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