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Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis.


ABSTRACT: OBJECTIVE:To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia. DESIGN:Systematic overview and meta-regression analyses of randomised controlled trials, as a basis for formal development of guidelines. SUBJECTS:12 649 patients in 52 randomised trials comparing atypical antipsychotics (amisulpride, clozapine, olanzapine, quetiapine, risperidone, and sertindole) with conventional antipsychotics (usually haloperidol or chlorpromazine) or alternative atypical antipsychotics. MAIN OUTCOME MEASURES:Overall symptom scores. Rate of drop out (as a proxy for tolerability) and of side effects, notably extrapyramidal side effects. RESULTS:For both symptom reduction and drop out, there was substantial heterogeneity between the results of trials, including those evaluating the same atypical antipsychotic and comparator drugs. Meta-regression suggested that dose of conventional antipsychotic explained the heterogeneity. When the dose was

SUBMITTER: Geddes J 

PROVIDER: S-EPMC27538 | biostudies-literature | 2000 Dec

REPOSITORIES: biostudies-literature

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Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis.

Geddes J J   Freemantle N N   Harrison P P   Bebbington P P  

BMJ (Clinical research ed.) 20001201 7273


<h4>Objective</h4>To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia.<h4>Design</h4>Systematic overview and meta-regression analyses of randomised controlled trials, as a basis for formal development of guidelines.<h4>Subjects</h4>12 649 patients in 52 randomised trials comparing atypical antipsychotics (amisulpride, clozapine, olanzapine, quetiapine, risperidone, and sertindole) with conventional antipsychotics (usually haloperi  ...[more]

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