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Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging.


ABSTRACT: We have developed a size series of unusually small, water-soluble (InAs)ZnSe (core)shell quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including multiple sequential lymph node mapping and extravasation from the vasculature. The biological utility of these fluorescent probes resulted from our intentional choice to match the semiconductor material and water-soluble ligand with a desired final hydrodynamic diameter and emission wavelength.

SUBMITTER: Zimmer JP 

PROVIDER: S-EPMC2753875 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature

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Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging.

Zimmer John P JP   Kim Sang-Wook SW   Ohnishi Shunsuke S   Tanaka Eichii E   Frangioni John V JV   Bawendi Moungi G MG  

Journal of the American Chemical Society 20060301 8


We have developed a size series of unusually small, water-soluble (InAs)ZnSe (core)shell quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including multiple sequential lymph node mapping and extravasation from the vasculature. The biological utility of these fluorescent probes resulted from our intentional choice to match the semiconductor material and water-soluble ligand with a desired final hydrodynamic diameter and emission wavelength. ...[more]

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