Ontology highlight
ABSTRACT:
SUBMITTER: Park SR
PROVIDER: S-EPMC2753990 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Nature immunology 20090412 5
The cytidine deaminase AID (encoded by Aicda in mice and AICDA in humans) is critical for immunoglobulin class-switch recombination (CSR) and somatic hypermutation (SHM). Here we show that AID expression was induced by the HoxC4 homeodomain transcription factor, which bound to a highly conserved HoxC4-Oct site in the Aicda or AICDA promoter. This site functioned in synergy with a conserved binding site for the transcription factors Sp1, Sp3 and NF-kappaB. HoxC4 was 'preferentially' expressed in ...[more]