Ontology highlight
ABSTRACT:
SUBMITTER: Maddika S
PROVIDER: S-EPMC2754075 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Maddika Subbareddy S Chen Junjie J
Nature cell biology 20090315 4
Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP proteins (EDVP complex). Strikingly, DYRK2 serves as a scaffold for the EDVP complex, because small-interfering-RNA-mediated depletion of DYRK2 disrupts the formation of the EDD-DDB1-V ...[more]