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Identification and comparison of eleven rhesus macaque chemokine receptors.

ABSTRACT: Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors, with or without CD4, as portals for entry into susceptible cells. In this report, we present the cloning and comparison of 11 rhesus macaque chemokine receptors and receptor-like proteins (CCR1, CCR2b, CCR3, CCR5, CCR8, CXCR4, STRL33, GPR1, GPR15, APJ, and CRAM-A/B), the human counterparts of which have been previously shown to be utilized by SIV for entry.

SUBMITTER: Margulies BJ

PROVIDER: S-EPMC2754205 | biostudies-literature | 2001 Jul

REPOSITORIES: biostudies-literature

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Identification and comparison of eleven rhesus macaque chemokine receptors.

Margulies B J BJ Hauer D A DA Clements J E JE

AIDS research and human retroviruses 20010701 10

Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors, with or without CD4, as portals for entry into susceptible cells. In this report, we present the cloning and comparison of 11 rhesus macaque chemokine receptors and receptor-like proteins (CCR1, CCR2b, CCR3, CCR5, CCR8, CXCR4, STRL33, GPR1, GPR15, APJ, and CRAM-A/B), the human counterparts of which have been previously shown to be utilized by SIV for entry. ...[more]

PMID: 11461684

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