Ontology highlight
ABSTRACT:
SUBMITTER: Sempombe J
PROVIDER: S-EPMC2754207 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Sempombe Joseph J Elmore Bradley O BO Sun Xi X Dupont Andrea A Ghosh Dipak K DK Guillemette J Guy JG Kirk Martin L ML Feng Changjian C
Journal of the American Chemical Society 20090501 20
The nitric oxide synthase (NOS) output state for NO production is a complex of the flavin mononucleotide (FMN)-binding domain and the heme domain, and thereby it facilitates the interdomain electron transfer from the FMN to the catalytic heme site. Emerging evidence suggests that interdomain FMN-heme interactions are important in the formation of the output state because they guide the docking of the FMN domain to the heme domain. In this study, notable effects of mutations in the adjacent FMN d ...[more]