Ontology highlight
ABSTRACT:
SUBMITTER: Hurst DR
PROVIDER: S-EPMC2754225 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Hurst Douglas R DR Edmonds Mick D MD Scott Gary K GK Benz Christopher C CC Vaidya Kedar S KS Welch Danny R DR
Cancer research 20090203 4
Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that differentially regulates expression of multiple genes, leading to suppression of metastasis without blocking orthotopic tumor growth in multiple human and murine cancer cells of diverse origins. We hypothesized that miR-146 may be involved in the ability of BRMS1 to supress metastasis because miR-146 expression is altered by BRMS1 and because BRMS1 and miR-146 are both associated with decreased signaling throug ...[more]