Ontology highlight
ABSTRACT:
SUBMITTER: Coleman JR
PROVIDER: S-EPMC2754401 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Coleman J Robert JR Papamichail Dimitris D Skiena Steven S Futcher Bruce B Wimmer Eckard E Mueller Steffen S
Science (New York, N.Y.) 20080601 5884
As a result of the redundancy of the genetic code, adjacent pairs of amino acids can be encoded by as many as 36 different pairs of synonymous codons. A species-specific "codon pair bias" provides that some synonymous codon pairs are used more or less frequently than statistically predicted. We synthesized de novo large DNA molecules using hundreds of over-or underrepresented synonymous codon pairs to encode the poliovirus capsid protein. Underrepresented codon pairs caused decreased rates of pr ...[more]