Ontology highlight
ABSTRACT:
SUBMITTER: Onclercq-Delic R
PROVIDER: S-EPMC275476 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Onclercq-Delic Rosine R Calsou Patrick P Delteil Christine C Salles Bernard B Papadopoulo Dora D Amor-Guéret Mounira M
Nucleic acids research 20031101 21
Bloom's syndrome (BS) which associates genetic instability and predisposition to cancer is caused by mutations in the BLM gene encoding a RecQ family 3'-5' DNA helicase. It has been proposed that the generation of genetic instability in BS cells could result from an aberrant non-homologous DNA end joining (NHEJ), one of the two main DNA double-strand break (DSB) repair pathways in mammalian cells, the second major pathway being homologous recombination (HR). Using cell extracts, we report first ...[more]