Ontology highlight
ABSTRACT:
SUBMITTER: Lawrence HR
PROVIDER: S-EPMC2754843 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Lawrence Harshani R HR Li Zhenyu Z Yip M L Richard ML Sung Shen-Shu SS Lawrence Nicholas J NJ McLaughlin Mark L ML McManus Gregory J GJ Zaworotko Michael J MJ Sebti Saïd M SM Chen Jiandong J Guida Wayne C WC
Bioorganic & medicinal chemistry letters 20090503 14
NSC 333003 has been identified from the NCI Diversity Set as an inhibitor of the MDM2-p53 protein-protein interaction by in silico docking (virtual screening). Its potency and chemical characteristics render it well suited for lead optimization studies that can result in more potent analogs with improved drug-like properties. Its synthesis was achieved using an acid catalyzed condensation reaction from commercially available benzothiazole hydrazine and pyridyl phenyl ketone in refluxing methanol ...[more]