Ontology highlight
ABSTRACT:
SUBMITTER: Radhakrishnan Y
PROVIDER: S-EPMC2754882 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Radhakrishnan Yashwanth Y Hamil Katherine G KG Tan Jiann-An JA Grossman Gail G Petrusz Peter P Hall Susan H SH French Frank S FS
Biology of reproduction 20090617 4
Human sperm-associated antigen 11 (SPAG11) is closely related to beta-defensins in structure, expression, and function. Like the beta-defensins, SPAG11 proteins are predominantly expressed in the male reproductive tract, where their best-known major roles are in innate host defense and reproduction. Although several hypotheses have emerged to describe the evolution of beta-defensin and SPAG11 multifunctionality, few describe these multiple functions in terms of defensin interactions with specifi ...[more]