Ontology highlight
ABSTRACT:
SUBMITTER: Gurley KA
PROVIDER: S-EPMC2755502 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Gurley Kyle A KA Rink Jochen C JC Sánchez Alvarado Alejandro A
Science (New York, N.Y.) 20071206 5861
After amputation, freshwater planarians properly regenerate a head or tail from the resulting anterior or posterior wound. The mechanisms that differentiate anterior from posterior and direct the replacement of the appropriate missing body parts are unknown. We found that in the planarian Schmidtea mediterranea, RNA interference (RNAi) of beta-catenin or dishevelled causes the inappropriate regeneration of a head instead of a tail at posterior amputations. Conversely, RNAi of the beta-catenin an ...[more]