Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC2755554 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Li Jingzhi J Qian Xinguo X Sha Bingdong B
Protein and peptide letters 20090101 6
The mechanism by which Hsp40 and other molecular chaperones recognize and interact with non-native polypeptides is a fundamental question, as is how Hsp40 co-operates with Hsp70 to facilitate protein folding. Years of structural studies of Hsp40 from yeast and other species, conducted using X-ray protein crystallography, NMR and small-angle X-ray scattering, have shed light on the mechanisms how Hsp40 functions as a molecular chaperone and how Hsp40-Hsp70 pair promotes protein folding, protein t ...[more]