Ontology highlight
ABSTRACT:
SUBMITTER: Sun B
PROVIDER: S-EPMC2755563 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Sun Binggui B Zhou Yungui Y Halabisky Brian B Lo Iris I Cho Seo-Hyun SH Mueller-Steiner Sarah S Devidze Nino N Wang Xin X Grubb Anders A Gan Li L
Neuron 20081001 2
Impaired degradation of amyloid beta (Abeta) peptides could lead to Abeta accumulation, an early trigger of Alzheimer's disease (AD). How Abeta-degrading enzymes are regulated remains largely unknown. Cystatin C (CysC, CST3) is an endogenous inhibitor of cysteine proteases, including cathepsin B (CatB), a recently discovered Abeta-degrading enzyme. A CST3 polymorphism is associated with an increased risk of late-onset sporadic AD. Here, we identified CysC as the key inhibitor of CatB-induced Abe ...[more]