Ontology highlight
ABSTRACT:
SUBMITTER: Chambers AL
PROVIDER: S-EPMC275562 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Chambers A L AL Smith A J AJ Savery N J NJ
Nucleic acids research 20031101 22
The bacterial transcription-repair coupling factor, Mfd, is a superfamily II helicase that releases transcription elongation complexes stalled by DNA damage or other obstacles. Transcription complex displacement is an ATP-dependent reaction that is thought to involve DNA translocation without the strand separation associated with classical helicase activity. We have identified single amino acid substitutions within Mfd that disrupt the ability of Mfd to displace RNA polymerase but do not prevent ...[more]