Ontology highlight
ABSTRACT:
SUBMITTER: D'Arco M
PROVIDER: S-EPMC2755864 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
D'Arco Marianna M Giniatullin Rashid R Leone Vanessa V Carloni Paolo P Birsa Nicol N Nair Asha A Nistri Andrea A Fabbretti Elsa E
The Journal of biological chemistry 20090609 32
On sensory neurons, sensitization of P2X(3) receptors gated by extracellular ATP contributes to chronic pain. We explored the possibility that receptor sensitization may arise from down-regulation of an intracellular signal negatively controlling receptor function. In view of the structural modeling between the Src region phosphorylated by the C-terminal Src inhibitory kinase (Csk) and the intracellular C terminus domain of the P2X(3) receptor, we investigated how Csk might regulate receptor act ...[more]