Ontology highlight
ABSTRACT:
SUBMITTER: Lin M
PROVIDER: S-EPMC2756013 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Lin Mauting M Morrison Carl D CD Jones Susie S Mohamed Nehad N Bacher Jason J Plass Christoph C
International journal of cancer 20090801 3
Gene amplification, a common mechanism for oncogene activation in cancers, has been used in the discovery of novel oncogenes. Low-level copy number gains are frequently observed in head and neck squamous cell carcinomas (HNSCCs) where numerous amplification events and potential oncogenes have already been reported. Recently, we applied restriction landmark genome scanning to study gene amplifications in HNSCC and located novel and uncharacterized regions in primary tumor samples. Gain on chromos ...[more]