Ontology highlight
ABSTRACT:
SUBMITTER: Oler JA
PROVIDER: S-EPMC2756094 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Oler Jonathan A JA Fox Andrew S AS Shelton Steven E SE Christian Bradley T BT Murali Dhanabalan D Oakes Terrence R TR Davidson Richard J RJ Kalin Ned H NH
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090801 32
The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission and is implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [(11)C]DASB [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperamen ...[more]