IL-21 mediates suppressive effects via its induction of IL-10.
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ABSTRACT:
SUBMITTER: Spolski R
PROVIDER: S-EPMC2756221 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
IL-21 mediates suppressive effects via its induction of IL-10.
Spolski Rosanne R Kim Hyoung-Pyo HP Zhu Wei W Levy David E DE Leonard Warren J WJ
Journal of immunology (Baltimore, Md. : 1950) 20090301 5
IL-21 is a pleiotropic cytokine that is required for normal Ig production. We previously showed that IL-21 was elevated in BXSB-Yaa mice with systemic lupus erythematosus. These mice also had elevated IL-10 levels, and we now show that IL-21 induces IL-10 mRNA and protein, suggesting unexpected immunosuppressive activities for IL-21. Indeed, Th1 priming with IL-21 leads to accumulation of cells with immunosuppressive activity, and IL-21 overexpression decreases specific Ab production after immun ...[more]
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