Ontology highlight
ABSTRACT:
SUBMITTER: Tavtigian SV
PROVIDER: S-EPMC2756555 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Tavtigian Sean V SV Oefner Peter J PJ Babikyan Davit D Hartmann Anne A Healey Sue S Le Calvez-Kelm Florence F Lesueur Fabienne F Byrnes Graham B GB Chuang Shu-Chun SC Forey Nathalie N Feuchtinger Corinna C Gioia Lydie L Hall Janet J Hashibe Mia M Herte Barbara B McKay-Chopin Sandrine S Thomas Alun A Vallée Maxime P MP Voegele Catherine C Webb Penelope M PM Whiteman David C DC Sangrajrang Suleeporn S Hopper John L JL Southey Melissa C MC Andrulis Irene L IL John Esther M EM Chenevix-Trench Georgia G
American journal of human genetics 20090924 4
The susceptibility gene for ataxia telangiectasia, ATM, is also an intermediate-risk breast-cancer-susceptibility gene. However, the spectrum and frequency distribution of ATM mutations that confer increased risk of breast cancer have been controversial. To assess the contribution of rare variants in this gene to risk of breast cancer, we pooled data from seven published ATM case-control mutation-screening studies, including a total of 1544 breast cancer cases and 1224 controls, with data from o ...[more]