Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Yehoyada M
PROVIDER: S-EPMC2756577 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Molecular cell 20090901 5
DNA interstrand crosslinks (ICLs) are the most toxic lesions induced by chemotherapeutic agents such as mitomycin C and cisplatin. By covalently linking both DNA strands, ICLs prevent DNA melting, transcription, and replication. Studies on ICL signaling and repair have been limited, because these drugs generate additional DNA lesions that trigger checkpoint signaling. Here, we monitor sensing, signaling from, and repairing of a single site-specific ICL in cell-free extract derived from Xenopus e ...[more]