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Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds.


ABSTRACT: Novel methodology for the formation of amide bonds under neutral conditions is described. Evidence is presented that the active acyl donors are thio FCMA intermediates, generated from the reactions of thioacids with isonitriles.

SUBMITTER: Rao Y 

PROVIDER: S-EPMC2756580 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds.

Rao Yu Y   Li Xuechen X   Danishefsky Samuel J SJ  

Journal of the American Chemical Society 20090901 36


Novel methodology for the formation of amide bonds under neutral conditions is described. Evidence is presented that the active acyl donors are thio FCMA intermediates, generated from the reactions of thioacids with isonitriles. ...[more]

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