Ontology highlight
ABSTRACT:
SUBMITTER: Meacham CE
PROVIDER: S-EPMC2756700 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Meacham Corbin E CE Ho Emily E EE Dubrovsky Esther E Gertler Frank B FB Hemann Michael T MT
Nature genetics 20090927 10
Mouse models have markedly improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic experimentation. Here, we report the adaptation of loss-of-function screening to mouse models of cancer. Specifically, we have been able to introduce a library of shRNAs into individual mice using transplantable Emu-myc lymphoma cells. This approach has allowed us to screen nearly 1,000 genetic alterations in th ...[more]