Ontology highlight
ABSTRACT:
SUBMITTER: Desbordes SC
PROVIDER: S-EPMC2756729 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Desbordes Sabrina C SC Placantonakis Dimitris G DG Ciro Anthony A Socci Nicholas D ND Lee Gabsang G Djaballah Hakim H Studer Lorenz L
Cell stem cell 20080601 6
High-throughput screening (HTS) of chemical libraries has become a critical tool in basic biology and drug discovery. However, its implementation and the adaptation of high-content assays to human embryonic stem cells (hESCs) have been hampered by multiple technical challenges. Here we present a strategy to adapt hESCs to HTS conditions, resulting in an assay suitable for the discovery of small molecules that drive hESC self-renewal or differentiation. Use of this new assay has led to the identi ...[more]