Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi N
PROVIDER: S-EPMC2757006 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Immunity 20071201 6
The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Here we showed that TIM-4 is expressed on human and mouse macrophages and dendritic cells, and both TIM-4 and TIM-1 specifically bound phosphatidylserine (PS) on the surface of apoptotic cells but not any other phospholipid tested. TIM-4(+) peritoneal macrophages, TIM-1(+) kidney cells, and TIM-4- or TIM-1-transfected cells efficiently phagocytosed apoptotic cells, and phagocytosis could be blocked by TIM-4 ...[more]