DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease.
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ABSTRACT:
SUBMITTER: Keeling BH
PROVIDER: S-EPMC2757072 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
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DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease.
Keeling Brett H BH Vilariño-Güell Carles C Ross Owen A OA Wszolek Zbigniew K ZK Uitti Ryan J RJ Farrer Matthew J MJ
Neuroscience letters 20090612 2
Variants in the dopamine receptor D3 (DRD3) and HCLS1 binding protein 3 (HS1BP3) have been nominated as risk factors for essential tremor (ET). Although ET and Parkinson disease (PD) are considered different entities, they have many overlapping clinical and pathological features. We aim to evaluate the role of the Ser9Gly variant in DRD3 and Ala265Gly in HS1BP3 in PD development. To this end, we genotyped these two variants in a PD matched case-control series from the United States. Statistical ...[more]
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