Ontology highlight
ABSTRACT:
SUBMITTER: Toyama Y
PROVIDER: S-EPMC2757114 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Toyama Yusuke Y Peralta Xomalin G XG Wells Adrienne R AR Kiehart Daniel P DP Edwards Glenn S GS
Science (New York, N.Y.) 20080901 5896
Understanding cell morphogenesis during metazoan development requires knowledge of how cells and the extracellular matrix produce and respond to forces. We investigated how apoptosis, which remodels tissue by eliminating supernumerary cells, also contributes forces to a tissue (the amnioserosa) that promotes cell-sheet fusion (dorsal closure) in the Drosophila embryo. We showed that expression in the amnioserosa of proteins that suppress or enhance apoptosis slows or speeds dorsal closure, respe ...[more]