Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC2757928 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Chen Weijun W Lam Suvana S SS Srinath Hema H Jiang Zhaozhao Z Correia John J JJ Schiffer Celia A CA Fitzgerald Katherine A KA Lin Kai K Royer William E WE
Nature structural & molecular biology 20081005 11
Interferon regulatory factors (IRFs) are essential in the innate immune response and other physiological processes. Activation of these proteins in the cytoplasm is triggered by phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, which stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription. The crystal structure of the transactivation domain of pseudophosphorylated human IRF5 strikingly revea ...[more]