Ontology highlight
ABSTRACT:
SUBMITTER: Cannon JR
PROVIDER: S-EPMC2757935 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Cannon Jason R JR Tapias Victor V Na Hye Mee HM Honick Anthony S AS Drolet Robert E RE Greenamyre J Timothy JT
Neurobiology of disease 20090501 2
The systemic rotenone model of Parkinson's disease (PD) accurately replicates many aspects of the pathology of human PD and has provided insights into the pathogenesis of PD. The major limitation of the rotenone model has been its variability, both in terms of the percentage of animals that develop a clear-cut nigrostriatal lesion and the extent of that lesion. The goal here was to develop an improved and highly reproducible rotenone model of PD. In these studies, male Lewis rats in three age gr ...[more]