Ontology highlight
ABSTRACT:
SUBMITTER: Pesu M
PROVIDER: S-EPMC2758057 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Pesu Marko M Watford Wendy T WT Wei Lai L Xu Lili L Fuss Ivan I Strober Warren W Andersson John J Shevach Ethan M EM Quezado Martha M Bouladoux Nicolas N Roebroek Anton A Belkaid Yasmine Y Creemers John J O'Shea John J JJ
Nature 20080901 7210
Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins. It is induced in activated T cells and is reported to process a variety of substrates including the anti-inflammatory cytokine transforming growth factor (TGF)-beta1 (refs 2-4), but the non-redundant functions of furin versus other proprotein convertases in T cells are unclear. Here we show that conditional deletion of furin in T cells allowed for normal T-cell development but impaired ...[more]