Ontology highlight
ABSTRACT:
SUBMITTER: Ali MM
PROVIDER: S-EPMC2758099 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Ali M Meser MM Woods Mark M Caravan Peter P Opina Ana C L AC Spiller Marga M Fettinger James C JC Sherry A Dean AD
Chemistry (Weinheim an der Bergstrasse, Germany) 20080101 24
The design of effective pH responsive MRI contrast agents is a key goal in the development of new diagnostic methods for conditions such as kidney disease and cancer. A key factor determining the effectiveness of an agent is the difference between the relaxivity of the "on" state compared to that of the "off" state. In this paper, we demonstrate that it is possible to improve the pH-responsive action of a low molecular weight agent by conjugating it to a macromolecular construct. The synthesis o ...[more]