Ontology highlight
ABSTRACT:
SUBMITTER: Beer NL
PROVIDER: S-EPMC2758140 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Beer Nicola L NL Tribble Nicholas D ND McCulloch Laura J LJ Roos Charlotta C Johnson Paul R V PR Orho-Melander Marju M Gloyn Anna L AL
Human molecular genetics 20090730 21
Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein (GKRP; gene name GCKR). Fructose-6 and fructose-1 phosphate (F6P and F1P) enhance or reduce GKRP-mediated inhibition ...[more]