Synergistic roles of amelogenin and ameloblastin.
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ABSTRACT:
SUBMITTER: Hatakeyama J
PROVIDER: S-EPMC2758615 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Synergistic roles of amelogenin and ameloblastin.
Hatakeyama J J Fukumoto S S Nakamura T T Haruyama N N Suzuki S S Hatakeyama Y Y Shum L L Gibson C W CW Yamada Y Y Kulkarni A B AB
Journal of dental research 20090401 4
Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-/-)/Ambn(-/-) mice, not only was the ameloblast layer irregular and detached from the enamel surface, as in Ambn(-/-), but also, the enamel width was significantly reduced in the do ...[more]
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