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Coupling reactions of hindered isonitriles and hindered alkyl thioacids: Mechanistic studies.

ABSTRACT: The coupling reaction between hindered thioacids and isonitriles is developed and described. The mechanism for the formation of the thiopyruvamide products is explored, and the method is applied to a selection of substrates.

SUBMITTER: Stockdill JL 

PROVIDER: S-EPMC2758784 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Coupling reactions of hindered isonitriles and hindered alkyl thioacids: Mechanistic studies.

Stockdill Jennifer L JL   Wu Xiangyang X   Danishefsky Samuel J SJ  

Tetrahedron letters 20090901 36

The coupling reaction between hindered thioacids and isonitriles is developed and described. The mechanism for the formation of the thiopyruvamide products is explored, and the method is applied to a selection of substrates. ...[more]

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