Ontology highlight
ABSTRACT:
SUBMITTER: McTamney PM
PROVIDER: S-EPMC2758933 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
McTamney Patrick M PM Rokita Steven E SE
Journal of the American Chemical Society 20091001 40
Iodotyrosine deiodinase is essential for iodide homeostasis and proper thyroid function in mammals. This enzyme promotes a net reductive deiodination of 3-iodotyrosine to form iodide and tyrosine. Such a reductive dehalogenation is uncommon in aerobic organisms, and its requirement for flavin mononucleotide is even more uncommon in catalysis. Reducing equivalents are now shown to transfer directly from the flavin to the halogenated substrate without involvement of other components typically incl ...[more]